diff --git a/dd-java-agent/agent-bootstrap/src/main/java/datadog/trace/bootstrap/Agent.java b/dd-java-agent/agent-bootstrap/src/main/java/datadog/trace/bootstrap/Agent.java
index aae283da55c..876a07f1fd1 100644
--- a/dd-java-agent/agent-bootstrap/src/main/java/datadog/trace/bootstrap/Agent.java
+++ b/dd-java-agent/agent-bootstrap/src/main/java/datadog/trace/bootstrap/Agent.java
@@ -60,6 +60,7 @@
 import datadog.trace.bootstrap.instrumentation.jfr.InstrumentationBasedProfiling;
 import datadog.trace.util.AgentTaskScheduler;
 import datadog.trace.util.AgentThreadFactory.AgentThread;
+import datadog.trace.util.JDK9ModuleAccess;
 import datadog.trace.util.throwable.FatalAgentMisconfigurationError;
 import edu.umd.cs.findbugs.annotations.SuppressFBWarnings;
 import java.lang.instrument.Instrumentation;
@@ -659,6 +660,8 @@ public InstallDatadogTracerCallback(
       }
 
       installDatadogMeter(initTelemetry);
+      // Must run before installDatadogTracer, which triggers the ddprof profiler load.
+      prepareDatadogProfilerContextStorage(instrumentation);
       installDatadogTracer(initTelemetry, scoClass, sco);
       maybeInstallLogsIntake(scoClass, sco);
       maybeStartIast(instrumentation);
@@ -1356,6 +1359,33 @@ public void withTracer(TracerAPI tracer) {
         });
   }
 
+  /**
+   * Exports {@code jdk.internal.misc} to the classloader that loads {@code
+   * com.datadoghq.profiler.*} before the Datadog profiler is loaded.
+   *
+   * <p>On JDK 21+, the profiler scopes its context {@code ThreadContext} storage to the carrier
+   * thread using {@code jdk.internal.misc.CarrierThreadLocal}, so a mounted virtual thread resolves
+   * to its current carrier's record — fixing a virtual-thread context use-after-free. That type
+   * lives in a non-exported package, hence the export. Must run before {@code
+   * installDatadogTracer}, which loads the profiler via {@link
+   * #createProfilingContextIntegration()}.
+   */
+  private static void prepareDatadogProfilerContextStorage(Instrumentation inst) {
+    try {
+      if (inst == null
+          || !Config.get().isProfilingEnabled()
+          || !Config.get().isDatadogProfilerEnabled()
+          || OperatingSystem.isWindows()
+          || !isJavaVersionAtLeast(21)) {
+        return;
+      }
+      JDK9ModuleAccess.exportModuleToUnnamedModule(
+          inst, "java.base", new String[] {"jdk.internal.misc"}, AGENT_CLASSLOADER);
+    } catch (Throwable t) {
+      log.debug("Unable to export jdk.internal.misc for the Datadog profiler", t);
+    }
+  }
+
   /**
    * {@see com.datadog.profiling.ddprof.DatadogProfilingIntegration} must not be modified to depend
    * on JFR.