diff --git a/packages/core/src/integrations/http/client-subscriptions.ts b/packages/core/src/integrations/http/client-subscriptions.ts
index 554445eb8053..574141e8a260 100644
--- a/packages/core/src/integrations/http/client-subscriptions.ts
+++ b/packages/core/src/integrations/http/client-subscriptions.ts
@@ -184,9 +184,8 @@ export function getHttpClientSubscriptions(options: HttpInstrumentationOptions):
           if (breadcrumbs) {
             addBreadcrumbs(request, response);
           }
-          const aborted = response.aborted && !response.complete;
           const status: SpanStatus =
-            error || typeof response.statusCode !== 'number' || aborted
+            error || typeof response.statusCode !== 'number'
               ? { code: SPAN_STATUS_ERROR }
               : getSpanStatusFromHttpCode(response.statusCode);
           options.applyCustomAttributesOnSpan?.(span, request, response);
@@ -196,6 +195,9 @@ export function getHttpClientSubscriptions(options: HttpInstrumentationOptions):
 
       response.on('end', () => finishWithResponse());
       response.on(errorMonitor, finishWithResponse);
+      // `res.destroy()` emits only `close`. `errored` separates a caller destroy from a connection
+      // error that was not emitted because nothing listens for `error`.
+      response.on('close', () => finishWithResponse(response.errored));
     });
   };
 
diff --git a/packages/core/src/integrations/http/types.ts b/packages/core/src/integrations/http/types.ts
index 70c76fbf9256..7ec38a86fd4a 100644
--- a/packages/core/src/integrations/http/types.ts
+++ b/packages/core/src/integrations/http/types.ts
@@ -93,6 +93,7 @@ export interface HttpIncomingMessage {
   socket?: HttpSocket;
   aborted?: boolean;
   complete?: boolean;
+  errored?: Error | null;
   resume(): void;
   on(event: 'end', listener: () => void): this;
   on(event: string | symbol, listener: (...args: unknown[]) => void): this;
diff --git a/packages/core/test/lib/integrations/http/client-subscriptions.test.ts b/packages/core/test/lib/integrations/http/client-subscriptions.test.ts
index 74cf76467586..24962c79ae0d 100644
--- a/packages/core/test/lib/integrations/http/client-subscriptions.test.ts
+++ b/packages/core/test/lib/integrations/http/client-subscriptions.test.ts
@@ -1,4 +1,5 @@
 import * as http from 'node:http';
+import { errorMonitor } from 'node:events';
 import type { AddressInfo } from 'node:net';
 import { afterAll, afterEach, beforeAll, describe, expect, it, vi } from 'vitest';
 import * as breadcrumbModule from '../../../../src/integrations/http/add-outgoing-request-breadcrumb';
@@ -126,6 +127,10 @@ describe('getHttpClientSubscriptions', () => {
         res.writeHead(req.url === '/not-found' ? 404 : 200);
         // Keep the body open so that the request can be aborted after the response arrived.
         res.write('x');
+        if (req.url === '/server-abort') {
+          // The server goes away before the body is complete.
+          setTimeout(() => res.socket?.destroy(), 10);
+        }
       });
       await new Promise<void>(resolve => server.listen(0, '127.0.0.1', resolve));
       port = (server.address() as AddressInfo).port;
@@ -138,7 +143,14 @@ describe('getHttpClientSubscriptions', () => {
 
     function makeRequest(
       path: string,
-      abortAt: 'beforeResponse' | 'afterResponse' | 'destroyWithError',
+      abortAt:
+        | 'beforeResponse'
+        | 'afterResponse'
+        | 'destroyWithError'
+        | 'destroyResponse'
+        | 'destroyResponseWithError'
+        | 'never',
+      { listenForResponseErrors = true }: { listenForResponseErrors?: boolean } = {},
     ): Promise<SpanJSON> {
       const client = new TestClient(getDefaultTestClientOptions({ tracesSampleRate: 1 }));
       setCurrentClient(client);
@@ -154,15 +166,22 @@ describe('getHttpClientSubscriptions', () => {
         const controller = new AbortController();
         const request = http.request({ host: '127.0.0.1', port, path, signal: controller.signal });
         startSpan({ name: 'parent' }, () => {
-          getHttpClientSubscriptions({})[HTTP_ON_CLIENT_REQUEST]({ request }, HTTP_ON_CLIENT_REQUEST);
+          // Like @sentry/node, pass the real `errorMonitor`, so Sentry itself does not add an `error` listener.
+          getHttpClientSubscriptions({ errorMonitor })[HTTP_ON_CLIENT_REQUEST]({ request }, HTTP_ON_CLIENT_REQUEST);
         });
         request.on('error', () => {});
         request.on('response', response => {
-          response.on('error', () => {});
+          if (listenForResponseErrors) {
+            response.on('error', () => {});
+          }
           response.once('data', () => {
             if (abortAt === 'destroyWithError') {
               request.destroy(new Error('boom'));
-            } else {
+            } else if (abortAt === 'destroyResponse') {
+              response.destroy();
+            } else if (abortAt === 'destroyResponseWithError') {
+              response.destroy(new Error('boom'));
+            } else if (abortAt !== 'never') {
               controller.abort();
             }
           });
@@ -190,5 +209,28 @@ describe('getHttpClientSubscriptions', () => {
 
       expect(span.status).toBe('error');
     });
+
+    it('ends the span with the response status when the caller destroys the response mid-body', async () => {
+      expect((await makeRequest('/', 'destroyResponse')).status).toBe('ok');
+      expect((await makeRequest('/not-found', 'destroyResponse')).status).toBe('error');
+    });
+
+    it('ends the span with an error status when the response is destroyed with an error mid-body', async () => {
+      const span = await makeRequest('/', 'destroyResponseWithError');
+
+      expect(span.status).toBe('error');
+    });
+
+    it('sets an error status when the server closes the connection mid-body', async () => {
+      const span = await makeRequest('/server-abort', 'never');
+
+      expect(span.status).toBe('error');
+    });
+
+    it('sets an error status when the connection resets mid-body and nothing listens for response errors', async () => {
+      const span = await makeRequest('/server-abort', 'never', { listenForResponseErrors: false });
+
+      expect(span.status).toBe('error');
+    });
   });
 });