diff --git a/packages/django-google-spanner/django_spanner/schema.py b/packages/django-google-spanner/django_spanner/schema.py
index da57122bb73d..905e5843fe51 100644
--- a/packages/django-google-spanner/django_spanner/schema.py
+++ b/packages/django-google-spanner/django_spanner/schema.py
@@ -450,7 +450,10 @@ def add_index(self, model, index):
     def quote_value(self, value):
         # A more complete implementation isn't currently required.
         if isinstance(value, str):
-            return "'%s'" % value.replace("'", "''")
+            # GoogleSQL string literals use backslash escaping; '' quote
+            # doubling is not recognized, so escape the backslash first and
+            # then the quote (matching the db_default/generated inlining above).
+            return "'%s'" % value.replace("\\", "\\\\").replace("'", "\\'")
         if isinstance(value, bool):
             return "TRUE" if value else "FALSE"
         return str(value)
diff --git a/packages/django-google-spanner/tests/unit/django_spanner/test_schema.py b/packages/django-google-spanner/tests/unit/django_spanner/test_schema.py
index b7ef7cec39ec..0ce848f9afe3 100644
--- a/packages/django-google-spanner/tests/unit/django_spanner/test_schema.py
+++ b/packages/django-google-spanner/tests/unit/django_spanner/test_schema.py
@@ -40,6 +40,19 @@ def test_quote_value(self):
         schema_editor = DatabaseSchemaEditor(self.connection)
         self.assertEqual(schema_editor.quote_value(value=1.1), "1.1")
 
+    def test_quote_value_escapes_string(self):
+        """
+        String literals must be backslash-escaped for GoogleSQL. A quote or
+        backslash in the value must not be able to terminate the literal.
+        """
+        schema_editor = DatabaseSchemaEditor(self.connection)
+        self.assertEqual(schema_editor.quote_value(value="o'brien"), "'o\\'brien'")
+        self.assertEqual(schema_editor.quote_value(value="a\\b"), "'a\\\\b'")
+        self.assertEqual(
+            schema_editor.quote_value(value="\\'; DROP TABLE t; --"),
+            "'\\\\\\'; DROP TABLE t; --'",
+        )
+
     def test_skip_default(self):
         """
         Tries skipping default as Cloud spanner doesn't support it.