diff --git a/frontend/e2e/accessibility.spec.ts b/frontend/e2e/accessibility.spec.ts
index c7017b466b..bd671ae684 100644
--- a/frontend/e2e/accessibility.spec.ts
+++ b/frontend/e2e/accessibility.spec.ts
@@ -199,6 +199,50 @@ test.describe("Accessibility", () => {
     await expect(page.locator(":focus")).toBeVisible();
   });
 
+  test("skip link is the first Tab stop, becomes visible on focus, and moves focus to main on activation", async ({
+    page,
+  }) => {
+    // Mock everything the app calls while booting, so this test does not
+    // depend on the dev-server proxy having a real backend behind it (see
+    // the same technique in labels-operation-picker.spec.ts). The shared
+    // beforeEach above already navigated once before these routes existed,
+    // so reload to get a fresh, intercepted navigation.
+    await page.route(/\/api\//, async (route) => {
+      const path = new URL(route.request().url()).pathname.replace(/^\/api/, "");
+      const json = (body: unknown) =>
+        route.fulfill({
+          status: 200,
+          contentType: "application/json",
+          body: JSON.stringify(body),
+        });
+      if (path === "/health") return json({ status: "healthy" });
+      if (path === "/auth/config") {
+        return json({ clientId: "", tenantId: "", allowedGroupIds: "" });
+      }
+      if (path === "/version") return json({ version: "a11y-test", display: "a11y-test" });
+      if (path === "/labels") {
+        return json({ source: "attacks", labels: { operator: ["roakey"], operation: [] } });
+      }
+      if (path === "/attacks") return json({ items: [], total: 0, limit: 5, offset: 0 });
+      return json({});
+    });
+    await page.reload();
+
+    await expect(page.getByTitle("Home")).toBeVisible();
+
+    const skipLink = page.getByRole("link", { name: "Skip to main content" });
+    await expect(skipLink).not.toBeInViewport();
+
+    // See the note on "should be navigable with keyboard" above: dispatch
+    // through `body` to guarantee the document has focus when Tab fires.
+    await page.locator("body").press("Tab");
+    await expect(skipLink).toBeFocused();
+    await expect(skipLink).toBeInViewport({ ratio: 1 });
+
+    await page.keyboard.press("Enter");
+    await expect(page.locator("#main-content")).toBeFocused();
+  });
+
   test("should have proper focus management", async ({ page }) => {
     // Mock a target so the input is enabled
     await page.route(/\/api\/targets/, async (route) => {
diff --git a/frontend/src/components/Layout/MainLayout.styles.ts b/frontend/src/components/Layout/MainLayout.styles.ts
index 83d2dec345..e9670a730b 100644
--- a/frontend/src/components/Layout/MainLayout.styles.ts
+++ b/frontend/src/components/Layout/MainLayout.styles.ts
@@ -8,6 +8,30 @@ export const useMainLayoutStyles = makeStyles({
     width: '100vw',
     overflow: 'hidden',
   },
+  skipLink: {
+    position: 'absolute',
+    top: '0',
+    left: '0',
+    zIndex: 1000,
+    padding: `${tokens.spacingVerticalS} ${tokens.spacingHorizontalM}`,
+    backgroundColor: tokens.colorBrandBackground,
+    color: tokens.colorNeutralForegroundOnBrand,
+    fontWeight: tokens.fontWeightSemibold,
+    textDecorationLine: 'none',
+    borderBottomRightRadius: tokens.borderRadiusMedium,
+    // translateY(-100%) hides the link above the viewport regardless of its
+    // own rendered height (text zoom, a different font, or longer copy can
+    // all change that height), unlike a fixed 'top' offset.
+    transform: 'translateY(-100%)',
+    transitionProperty: 'transform',
+    transitionDuration: tokens.durationFast,
+    '@media (prefers-reduced-motion: reduce)': {
+      transitionDuration: '0s',
+    },
+    ':focus-visible': {
+      transform: 'translateY(0)',
+    },
+  },
   topBar: {
     height: '60px',
     backgroundColor: tokens.colorNeutralBackground3,
diff --git a/frontend/src/components/Layout/MainLayout.test.tsx b/frontend/src/components/Layout/MainLayout.test.tsx
index 3cd1412c16..e93f73d383 100644
--- a/frontend/src/components/Layout/MainLayout.test.tsx
+++ b/frontend/src/components/Layout/MainLayout.test.tsx
@@ -231,4 +231,32 @@ describe("MainLayout", () => {
       expect(mockedVersionApi.getVersion).toHaveBeenCalled();
     });
   });
+
+  it("renders a skip link as the first focusable element that targets the main landmark", async () => {
+    mockedVersionApi.getVersion.mockResolvedValue({ version: "1.0.0" });
+
+    const { container } = renderWithProvider(
+      <MainLayout {...defaultProps}>
+        <div>Content</div>
+      </MainLayout>
+    );
+
+    const skipLink = screen.getByRole("link", { name: /skip to main content/i });
+    expect(skipLink).toHaveAttribute("href", "#main-content");
+
+    const main = container.querySelector("main");
+    expect(main).toHaveAttribute("id", "main-content");
+    expect(main).toHaveAttribute("tabIndex", "-1");
+
+    // The skip link must be the first focusable element in the shell so
+    // keyboard users reach it on the very first Tab press.
+    const focusable = container.querySelectorAll<HTMLElement>(
+      'a[href], button, [tabindex]:not([tabindex="-1"])'
+    );
+    expect(focusable[0]).toBe(skipLink);
+
+    await waitFor(() => {
+      expect(mockedVersionApi.getVersion).toHaveBeenCalled();
+    });
+  });
 });
diff --git a/frontend/src/components/Layout/MainLayout.tsx b/frontend/src/components/Layout/MainLayout.tsx
index a106fbc497..4cea9256e6 100644
--- a/frontend/src/components/Layout/MainLayout.tsx
+++ b/frontend/src/components/Layout/MainLayout.tsx
@@ -44,6 +44,9 @@ export default function MainLayout({
 
   return (
     <div className={styles.root}>
+      <a href="#main-content" className={styles.skipLink}>
+        Skip to main content
+      </a>
       <div className={styles.topBar}>
         <Tooltip
           content={
@@ -86,7 +89,9 @@ export default function MainLayout({
             canManageConfiguration={canManageConfiguration}
           />
         </aside>
-        <main className={styles.main}>{children}</main>
+        <main id="main-content" tabIndex={-1} className={styles.main}>
+          {children}
+        </main>
       </div>
     </div>
   )