diff --git a/canvas/src/components/panel/PanelNodeLayer.test.tsx b/canvas/src/components/panel/PanelNodeLayer.test.tsx
new file mode 100644
index 000000000..9399d68ea
--- /dev/null
+++ b/canvas/src/components/panel/PanelNodeLayer.test.tsx
@@ -0,0 +1,82 @@
+// Copyright The Perses Authors
+// Licensed under the Apache License, Version 2.0 (the "License");
+// you may not use this file except in compliance with the License.
+// You may obtain a copy of the License at
+//
+// http://www.apache.org/licenses/LICENSE-2.0
+//
+// Unless required by applicable law or agreed to in writing, software
+// distributed under the License is distributed on an "AS IS" BASIS,
+// WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied.
+// See the License for the specific language governing permissions and
+// limitations under the License.
+
+import type { VariableStateMap } from '@perses-dev/components';
+import type * as PluginSystemModule from '@perses-dev/plugin-system';
+import { fireEvent, render, screen } from '@testing-library/react';
+import { vi } from 'vitest';
+
+import type { CanvasTheme } from '../../hooks/useCanvasTheme';
+import type { CanvasSpec } from '../../model';
+import { PanelNodeLayer } from './PanelNodeLayer';
+
+vi.mock('@perses-dev/plugin-system', async (importOriginal) => ({
+  ...(await importOriginal<typeof PluginSystemModule>()),
+  useAllVariableValues: (): VariableStateMap => ({
+    host: { value: 'example.com', loading: false },
+    target: { value: 'javascript:alert(document.domain)', loading: false },
+  }),
+}));
+
+vi.mock('../../hooks/useCanvasTheme', () => ({
+  useCanvasTheme: (): Pick<CanvasTheme, 'connection' | 'nodeDefaultFill'> => ({
+    connection: '#000000',
+    nodeDefaultFill: '#ffffff',
+  }),
+}));
+
+function renderNode(url: string): void {
+  const spec: CanvasSpec = {
+    nodes: [{ id: 'node', position: { x: 0, y: 0 }, width: 40, height: 40, kind: 'text', label: 'node', url }],
+  };
+  render(
+    <svg>
+      <PanelNodeLayer spec={spec} seriesByQueryIndex={new Map()} k={1} paletteColors={[]} />
+    </svg>,
+  );
+}
+
+describe('PanelNodeLayer', () => {
+  const open = vi.spyOn(window, 'open').mockReturnValue(null);
+
+  beforeEach(() => {
+    open.mockClear();
+  });
+
+  it('opens the interpolated URL of a node in a new tab', () => {
+    renderNode('https://$host/status');
+    fireEvent.click(screen.getByText('node'));
+    expect(open).toHaveBeenCalledWith('https://example.com/status', '_blank', 'noopener,noreferrer');
+  });
+
+  it('opens a relative URL', () => {
+    renderNode('/projects/demo/dashboards/demo');
+    fireEvent.click(screen.getByText('node'));
+    expect(open).toHaveBeenCalledWith('/projects/demo/dashboards/demo', '_blank', 'noopener,noreferrer');
+  });
+
+  it.each(['javascript:alert(document.domain)', ' JaVa\tScRiPt:alert(1)', 'data:text/html,<script>alert(1)</script>'])(
+    'does not open the URL %j',
+    (url) => {
+      renderNode(url);
+      fireEvent.click(screen.getByText('node'));
+      expect(open).not.toHaveBeenCalled();
+    },
+  );
+
+  it('does not open a URL whose scheme is provided by a variable', () => {
+    renderNode('$target');
+    fireEvent.click(screen.getByText('node'));
+    expect(open).not.toHaveBeenCalled();
+  });
+});
diff --git a/canvas/src/components/panel/PanelNodeLayer.tsx b/canvas/src/components/panel/PanelNodeLayer.tsx
index 497d7ad8d..5416539f3 100644
--- a/canvas/src/components/panel/PanelNodeLayer.tsx
+++ b/canvas/src/components/panel/PanelNodeLayer.tsx
@@ -11,6 +11,7 @@
 // See the License for the specific language governing permissions and
 // limitations under the License.
 
+import { sanitizeUrl } from '@perses-dev/components';
 import { replaceVariablesInString, useAllVariableValues } from '@perses-dev/plugin-system';
 import type { TimeSeries } from '@perses-dev/spec';
 import type { ReactElement } from 'react';
@@ -84,7 +85,11 @@ export function PanelNodeLayer({
 
   const handleNodeClick = useCallback(
     (url: string) => {
-      window.open(replaceVariablesInString(url, variableValues), '_blank', 'noopener,noreferrer');
+      // The URL is verified once interpolated, as a variable can provide its scheme (e.g. javascript:).
+      const href = sanitizeUrl(replaceVariablesInString(url, variableValues));
+      if (href) {
+        window.open(href, '_blank', 'noopener,noreferrer');
+      }
     },
     [variableValues],
   );