diff --git a/rules-tests/CodeQuality/Rector/MethodCall/WillReturnCallbackFallbackToReturnFalseRector/Fixture/skip_trailing_comment_after_return.php.inc b/rules-tests/CodeQuality/Rector/MethodCall/WillReturnCallbackFallbackToReturnFalseRector/Fixture/skip_trailing_comment_after_return.php.inc
new file mode 100644
index 00000000..5332d6e5
--- /dev/null
+++ b/rules-tests/CodeQuality/Rector/MethodCall/WillReturnCallbackFallbackToReturnFalseRector/Fixture/skip_trailing_comment_after_return.php.inc
@@ -0,0 +1,20 @@
+<?php
+
+namespace Rector\PHPUnit\Tests\CodeQuality\Rector\MethodCall\WillReturnCallbackFallbackToReturnFalseRector\Fixture;
+
+use PHPUnit\Framework\TestCase;
+
+final class SkipTrailingCommentAfterReturn extends TestCase
+{
+    public function test()
+    {
+        $callSequence = [];
+
+        $queueMock = $this->createMock(\stdClass::class);
+        $queueMock->expects($this->atLeastOnce())->method('isEmpty')->willReturnCallback(static function () use (&$callSequence): bool {
+            $callSequence[] = 'isEmpty';
+
+            return true; // Exit loop immediately
+        });
+    }
+}
diff --git a/rules/CodeQuality/Rector/MethodCall/WillReturnCallbackFallbackToReturnFalseRector.php b/rules/CodeQuality/Rector/MethodCall/WillReturnCallbackFallbackToReturnFalseRector.php
index 820fcc98..6b444601 100644
--- a/rules/CodeQuality/Rector/MethodCall/WillReturnCallbackFallbackToReturnFalseRector.php
+++ b/rules/CodeQuality/Rector/MethodCall/WillReturnCallbackFallbackToReturnFalseRector.php
@@ -8,6 +8,7 @@
 use PhpParser\Node\Expr\Closure;
 use PhpParser\Node\Expr\ConstFetch;
 use PhpParser\Node\Expr\MethodCall;
+use PhpParser\Node\Stmt\Nop;
 use PhpParser\Node\Stmt\Return_;
 use Rector\PhpParser\Node\BetterNodeFinder;
 use Rector\PHPUnit\NodeAnalyzer\TestsNodeAnalyzer;
@@ -123,8 +124,10 @@ public function refactor(Node $node): ?MethodCall
             return null;
         }
 
-        // already ends with an explicit return, no fallback needed
-        $lastStmt = $closure->stmts[count($closure->stmts) - 1];
+        // already ends with an explicit return, no fallback needed;
+        // skip trailing comment-only Nop statements added by a trailing comment
+        $stmts = array_filter($closure->stmts, static fn (Node $stmt): bool => ! $stmt instanceof Nop);
+        $lastStmt = end($stmts);
         if ($lastStmt instanceof Return_) {
             return null;
         }