ASO CSF Biomarker Live Coding Exercise

This repo contains a lightweight environment for a 45-minute live coding session.

Scenario (for candidates)

You will work with synthetic CSF omics data from a small ASO trial targeting a CNS gene (Gene X). There are 20 subjects (ASO vs placebo), each with baseline and week4 CSF proteomics and transcriptomics.

Your goals in the session:

• Sanity-check and join the data
• Compute within-subject baseline -> week4 changes
• Compare ASO vs placebo
• Propose candidate CSF biomarkers of target engagement

Files

• data/meta.csv
• data/proteome.csv
• data/transcriptome.csv
• livecoding.ipynb – starter notebook

Codespaces usage

Open a Codespace for this repo, then open livecoding.ipynb.