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Experimental design should be able to average over an ensemble, not only compute at the best fit
exploratoryExploratory/optional: an open question or proposal to evaluate before committing to buildExploratory/optional: an open question or proposal to evaluate before committing to buildStatus: Open.#669 In lanl/PyBNF;Learn the differential evolution mutation settings during a run instead of asking the user for them
enhancementNew feature or requestNew feature or requestStatus: Open.#667 In lanl/PyBNF;BNGL parameters defined by an expression are silently dropped when building a PEtab problem
bugSomething isn't workingSomething isn't workinghigh priorityUrgent or important workUrgent or important workStatus: Open.#666 In lanl/PyBNF;Investigate synthetic likelihood as a principled objective for stochastic models
exploratoryExploratory/optional: an open question or proposal to evaluate before committing to buildExploratory/optional: an open question or proposal to evaluate before committing to buildquestionFurther information is requestedFurther information is requestedStatus: Open.#665 In lanl/PyBNF;Build a parameter recovery benchmark for fitting stochastic rule-based models
enhancementNew feature or requestNew feature or requestStatus: Open.#663 In lanl/PyBNF;Stop hopeless starts early in a multi-start fit instead of running every one to completion
enhancementNew feature or requestNew feature or requestStatus: Open.#662 In lanl/PyBNF;CMA-ES ranks its population from single noisy simulations, so it misreads stochastic models
bugSomething isn't workingSomething isn't workingStatus: Open.#661 In lanl/PyBNF;Epic: finish the scatter search template, then make the reference set aware of simulation noise
enhancementNew feature or requestNew feature or requestStatus: Open.#660 In lanl/PyBNF;Best fit from a stochastic model is chosen from a single noisy simulation, so the reported objective is too good
bugSomething isn't workingSomething isn't workinghigh priorityUrgent or important workUrgent or important workStatus: Open.#659 In lanl/PyBNF;Report each start's final objective value at the end of a multi-start fit
enhancementNew feature or requestNew feature or requesthigh priorityUrgent or important workUrgent or important workStatus: Open.#658 In lanl/PyBNF;Retire register_bngl() + petab-spec CI machinery once a PyPI petab after 0.8.2 ships native BNGL
gatedBlocked on an external trigger, e.g. an upstream release; revisit when it firesBlocked on an external trigger, e.g. an upstream release; revisit when it firesStatus: Open.#591 In lanl/PyBNF;Investigate: ADR-0059 rejects simulator-path HMC on an unmeasured cost model ("~1x a solve per leapfrog") — measure it against the bngsim JAX bridge, and settle it with numbers either way
exploratoryExploratory/optional: an open question or proposal to evaluate before committing to buildExploratory/optional: an open question or proposal to evaluate before committing to buildStatus: Open.#576 In lanl/PyBNF;