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Screen antibody, TCR, and peptide sequences for developability liabilities — the motifs that cause deamidation, isomerization, fragmentation, unwanted glycosylation, oxidation, and cysteine problems.
Reproducible antibody developability workflow combining sequence and structure indicators with cautious viscosity analysis on published datasets.
Identifying potential liabilities in therapeutic antibody candidates using 3D structure analysis. Takes a protein structure in PDB format through preprocessing and liability detection to flag developability risks.
PhD project Github repository
Compute physicochemical properties (charge, GRAVY, pI, MW, ε) for peptide and antibody/TCR lead ranking
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